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Sore throats are common — but not all are created equal. Two frequent culprits, mononucleosis (mono) and strep throat, can look similar at first glance. Both cause throat pain, fatigue, and swollen glands, yet their causes and treatments couldn’t be more different.
Here’s how to recognize the difference so you can get the right care and recover faster.
What Is Mononucleosis (Mono)?
Mononucleosis is a viral infection caused by the Epstein-Barr Virus (EBV). It’s most common in teens and young adults and spreads easily through saliva — earning it the nickname “the kissing disease.”
Common symptoms include:
- Persistent fatigue
- Sore throat
- Swollen lymph nodes (neck, armpits, or groin)
- Low-grade fever
- Occasionally, an enlarged spleen
Mono symptoms develop gradually and can linger for several weeks, especially fatigue.
What Is Strep Throat?
Strep throat is a bacterial infection caused by Streptococcus pyogenes (Group A strep). Unlike mono, it spreads mainly through coughs, sneezes, and shared surfaces.
Key symptoms include:
- Sudden, severe sore throat
- Painful swallowing
- High fever
- Red, inflamed tonsils (often with white patches or pus)
- Swollen lymph nodes in the neck
With treatment, most people recover from strep throat in about 7–10 days.
Mono vs. Strep Throat: Quick Comparison
Treatment & Recovery
Mononucleosis (Viral):
- No antibiotics (they don’t treat viruses)
- Rest, hydration, and balanced nutrition
- Avoid strenuous activity for several weeks (risk of spleen rupture)
- Fatigue may linger for 1–2 months
Strep Throat (Bacterial):
- Requires antibiotics such as penicillin or amoxicillin
- Rest and fluids aid recovery
- Pain relievers (acetaminophen or ibuprofen) for fever and soreness
- Recovery typically within 7–10 days
When to See a Doctor
Contact your primary care provider if you experience:
- Severe sore throat with fever
- Difficulty swallowing or breathing
- Swollen glands or prolonged fatigue
- Abdominal pain (possible spleen enlargement)
- Symptoms lasting longer than 10 days
Expert Diagnosis & Care at BASS Medical Group
Whether it’s viral mono or bacterial strep, the right diagnosis makes all the difference.
At BASS Medical Group, our Primary Care and Infectious Disease Specialists offer accurate testing, treatment, and follow-up care across the Bay Area.
Request an appointment today and get back to feeling your best.
Frequently Asked Questions
1. Is mono more serious than strep throat?
Mono often causes longer-lasting fatigue, while strep throat clears faster with antibiotics. Both can have complications if left untreated.
2. Can you have mono and strep throat at the same time?
Yes, though rare. Some patients test positive for both the Epstein-Barr Virus and strep bacteria.
